Application of anti-CD3-treated lymphocytes as stimulator cells in human autologous mixed lymphocyte cultures for generation of autorestricted CD8 + suppressor T cells

The purpose of the present study was to investigate the application of anti-CD3-treated lymphocytes as stimulator cells in human one-way autologous mixed lymphocyte cultures (MLC) for the generation of suppressor cells. MLC-activated CD4 −CD8 + CD16 − T cells were non-cytotoxic, while they down-regu...

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Veröffentlicht in:	Immunology letters 1992-02, Vol.31 (3), p.233-236
Hauptverfasser:	Balashov, K.E., Brondz, B.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-CD3-induced T cell activation Antibodies, Monoclonal - immunology Antigens, CD - immunology Antigens, Differentiation - immunology Antigens, Differentiation, T-Lymphocyte - immunology Autologous mixed lymphocyte culture Biological and medical sciences CD3 Complex CD4-Positive T-Lymphocytes - immunology CD8 Antigens - immunology Cytotoxicity, Immunologic Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunological reactions in vitro Immunophenotyping Lymphoblastic transformation (stimulation by antigen, mitogen, mixed lymphocyte reactions) Lymphocyte Activation - immunology Lymphocyte Culture Test, Mixed Receptors, Antigen, T-Cell - immunology Receptors, Fc - immunology Receptors, IgG Suppressor T cell T-Lymphocytes - immunology T-Lymphocytes, Regulatory - immunology
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Zusammenfassung:	The purpose of the present study was to investigate the application of anti-CD3-treated lymphocytes as stimulator cells in human one-way autologous mixed lymphocyte cultures (MLC) for the generation of suppressor cells. MLC-activated CD4 −CD8 + CD16 − T cells were non-cytotoxic, while they down-regulated the proliferation of autologous (but not allogeneic) responder lymphocytes in allogeneic test MLC.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/0165-2478(92)90119-9