Histidine residues regulate the transition of photoexcited rhodopsin to its active conformation, metarhodopsin II

The biologically active photoproduct of rhodopsin, metarhodopsin II (M II), exists in a pH-sensitive equilibrium with its precursor, metarhodopsin I (M I). Increasing acidity favors M 11, with the midpoint of the pH titration curve at pH 6.4. To test the long-standing proposal that histidine protona...

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