The necessity to develop drugs against parasitic diseases

This review focuses on the most significant trends in the development of drugs for the treatment of malaria, African sleeping sickness and toxoplasmosis. In the case of malaria, those include new fixed-dose artemisinin combinations, antifolates and new targets in the apicoplast of Plasmodium falcipa...

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Veröffentlicht in:	Pharmazie 2002-11, Vol.57 (11), p.723-728
Hauptverfasser:	KAISER, A, GOTTWALD, A, WIERSCH, C, MAIER, W, SEITZ, H. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - therapeutic use Antiparasitic agents Biological and medical sciences Humans Malaria - drug therapy Malaria - epidemiology Medical sciences Parasitic Diseases - drug therapy Pharmacology. Drug treatments Toxoplasmosis - prevention & control Trypanosomiasis - drug therapy Vaccines
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Beschreibung
Zusammenfassung:	This review focuses on the most significant trends in the development of drugs for the treatment of malaria, African sleeping sickness and toxoplasmosis. In the case of malaria, those include new fixed-dose artemisinin combinations, antifolates and new targets in the apicoplast of Plasmodium falciparum. Targets in the treatment of trypanosomiasis are the biosynthesis of glycosylphosphatidylinositol and enzymes involved in the biosynthesis of trypanothione. Efforts to develop a vaccine against toxoplasmosis are discussed as well.
ISSN:	0031-7144