Low-dose tacrolimus for intractable myasthenia gravis

We treated two patients suffering from intractable myasthenia gravis (MG) with low-dose tacrolimus plus prednisolone. Both patients showed significant improvement of myasthenic signs, accompanied by suppressed serum anti-acetylcholine receptor antibody, waning in compound muscle action potential by...

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Veröffentlicht in:	Journal of clinical neuroscience 2002-11, Vol.9 (6), p.627-628
Hauptverfasser:	Yoshikawa, Hiroaki, Mabuchi, Kazunori, Yasukawa, Yoshihiro, Takamori, Masaharu, Yamada, Masahito
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Inflammatory Agents - administration & dosage Autoantibodies - immunology Biological and medical sciences Diseases of striated muscles. Neuromuscular diseases Drug Therapy, Combination Female Humans Immunomodulators Immunosuppressive Agents - administration & dosage Medical sciences Middle Aged Myasthenia Gravis - drug therapy Myasthenia Gravis - immunology myasthenia gravis, tacrolimus, immunotherapy Neurology Pharmacology. Drug treatments Prednisolone - administration & dosage Tacrolimus - administration & dosage
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Zusammenfassung:	We treated two patients suffering from intractable myasthenia gravis (MG) with low-dose tacrolimus plus prednisolone. Both patients showed significant improvement of myasthenic signs, accompanied by suppressed serum anti-acetylcholine receptor antibody, waning in compound muscle action potential by repetitive nerve stimulation and IL-2 production by peripheral blood mononuclear cells. Low-dose tacrolimus plus prednisolone is a promising therapeutic regimen for intractable MG.
ISSN:	0967-5868 1532-2653
DOI:	10.1054/jocn.2001.0907