TETRONOTHIODIN, A NOVEL CHOLECYSTOKININ TYPE-B RECEPTOR ANTAGONIST PRODUCED BY Streptomyces sp

TETRONOTHIODIN, A NOVEL CHOLECYSTOKININ TYPE-B RECEPTOR ANTAGONIST PRODUCED BY Streptomyces sp

Cholecystokinin (CCK) is a hormonal regulator of pancreatic secretion as well as gallbladder contraction and gut motility. It has also been proposed as a neurotransmitter in central nervous system. In our screening program for new binding inhibitors of brain-type CCK (CCK-B) receptors from microorga...

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Veröffentlicht in:Journal of antibiotics 1992/01/25, Vol.45(1), pp.140-143
Hauptverfasser: OHTSUKA, TATSUO, KUDOH, TSUTOMU, SHIMMA, NOBUO, KOTAKI, HIROMICHI, NAKAYAMA, NOBORU, ITEZONO, YOSHIKO, FUJISAKI, NORIKO, WATANABE, JUNKO, YOKOSE, KAZUTERU, SETO, HARUO
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - metabolism
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
Molecular Structure
Pancreas - metabolism
Rats
Receptors, Cholecystokinin - antagonists & inhibitors
Streptomyces
Streptomyces - metabolism
Thiophenes - chemistry
Thiophenes - isolation & purification
Thiophenes - pharmacology
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Zusammenfassung:Cholecystokinin (CCK) is a hormonal regulator of pancreatic secretion as well as gallbladder contraction and gut motility. It has also been proposed as a neurotransmitter in central nervous system. In our screening program for new binding inhibitors of brain-type CCK (CCK-B) receptors from microorganisms, we discovered a novel CCK-B receptor antagonist, tetronothiodin (1) from the culture filtrate of Streptomyces sp. NR0489. In this communication, we describe the fermentation, isolation, structural elucidation and biological properties of 1.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.140