Molecular virology of hepatitis C

Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Here, we will briefly review current concepts of the molecular virology of hepatitis C. In vitro and in vivo models of HCV replication will be discussed in this context...

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Veröffentlicht in:	Praxis (Bern. 1994) 2002-12, Vol.91 (51-52), p.2247-2253
Hauptverfasser:	Moradpour, D, Brass, V, Gosert, R, Wölk, B, Blum, H E
Format:	Artikel
Sprache:	ger
Schlagworte:	Animals Antiviral Agents - therapeutic use Cells, Cultured Disease Models, Animal Enzyme Inhibitors - therapeutic use Forecasting Genes, Viral Genetic Therapy Hepacivirus - enzymology Hepacivirus - genetics Hepacivirus - physiology Hepatitis C - complications Hepatitis C - drug therapy Hepatitis C - therapy Hepatitis C - virology Hepatocytes - virology Humans Mice Mice, Transgenic Pan troglodytes Polyproteins - genetics Polyproteins - metabolism Protease Inhibitors - therapeutic use Protein Biosynthesis Replicon - genetics RNA, Viral - genetics Transcription, Genetic Tumor Cells, Cultured Tupaia Viral Proteins - genetics Viral Proteins - metabolism Virus Replication
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Beschreibung
Zusammenfassung:	Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Here, we will briefly review current concepts of the molecular virology of hepatitis C. In vitro and in vivo models of HCV replication will be discussed in this context. Finally, novel antiviral strategies will be outlined that result from an improved understanding of the viral life cycle.
ISSN:	1661-8157