The Double Heterozygote of Two Endothelin-1 Gene Polymorphisms (G8002A and -3A/-4A) Is Related to Big Endothelin Levels in Chronic Heart Failure
The aim of this study was to focus on the relationship among the associated genotypes of G (8002) A and -3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/or biochemical parameters in Czech (Caucasian) patients with chronic heart failure. Included in the study were 103 patients wit...
Gespeichert in:
| Veröffentlicht in: | Experimental and molecular pathology 2002-12, Vol.73 (3), p.230-233 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 233 |
|---|---|
| container_issue | 3 |
| container_start_page | 230 |
| container_title | Experimental and molecular pathology |
| container_volume | 73 |
| creator | Vašků, A. Špinarová, L. Goldbergová, M. Mužik, J. Špinar, J. Vı́ tovec, J. Toman, J. Vácha, J. |
| description | The aim of this study was to focus on the relationship among the associated genotypes of G (8002) A and -3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/or biochemical parameters in Czech (Caucasian) patients with chronic heart failure. Included in the study were 103 patients with chronic heart failure (functional classes NYHA II–IV, ejection fraction |
| doi_str_mv | 10.1006/exmp.2002.2453 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72839036</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014480002924536</els_id><sourcerecordid>72839036</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-50eaa1ab61d6baae843e9a2e5cee1215a4f30cd87ccd3f268c8fbf2883adab2a3</originalsourceid><addsrcrecordid>eNp1kUGP0zAQhSMEYsvClSPyBQSHdMd2kjrHUna7K1UCoXK2JvZka-TExU4Wyq_gJ5OqlZYLp5nDN2-e3suy1xzmHKC6ol_dfi4AxFwUpXySzTjUVQ51UT7NZgC8yAsFcJG9SOk7ANTAxfPsgouyKhe1mmV_tjtin8LYeGK3NFAMvw_3YSAWWrb9Gdh1b8OwI-_6nLM19cS-BH_oQtzvXOoSe7-e5MWSYW9ZLpdXebH8wO4S-0oeB7JsCOyju_9Hhm3ogXxi07baxdA7M_3FOLAbdH6M9DJ71qJP9Oo8L7NvN9fb1W2--by-Wy03uSlkNeQlECLHpuK2ahBJFZJqFFQaIi54iUUrwVi1MMbKVlTKqLZphVISLTYC5WX27qS7j-HHSGnQnUuGvMeewpj0QihZg6wmcH4CTQwpRWr1ProO40Fz0McO9LEDfexAHzuYDt6clcemI_uIn0OfgLdnAJNB30bsjUuPXAFiMryYOHXiprzowVHUyTjqDVkXyQzaBvc_D38B1heiVg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72839036</pqid></control><display><type>article</type><title>The Double Heterozygote of Two Endothelin-1 Gene Polymorphisms (G8002A and -3A/-4A) Is Related to Big Endothelin Levels in Chronic Heart Failure</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Vašků, A. ; Špinarová, L. ; Goldbergová, M. ; Mužik, J. ; Špinar, J. ; Vı&#x0301;tovec, J. ; Toman, J. ; Vácha, J.</creator><creatorcontrib>Vašků, A. ; Špinarová, L. ; Goldbergová, M. ; Mužik, J. ; Špinar, J. ; Vı&#x0301;tovec, J. ; Toman, J. ; Vácha, J.</creatorcontrib><description>The aim of this study was to focus on the relationship among the associated genotypes of G (8002) A and -3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/or biochemical parameters in Czech (Caucasian) patients with chronic heart failure. Included in the study were 103 patients with chronic heart failure (functional classes NYHA II–IV, ejection fraction <40%). The ET-1 gene polymorphisms were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism methods. A significant decrease in the ET-1-associated genotype AG3A4A number (double heterozygote) was observed in CHF patients with plasma big endothelin levels above 0.7 pmol/L compared to those with levels below 0.7 pmol/L (OR = 0.19; 95% confidence interval = 0.06–0.57;
P = 0.005;
P
corr = 0.03). We found a significant decrease in the AG3A4A genotype number in the other groups compared to the group of patients with both big endothelin and endothelin-1 levels under 0.7 pmol/L (OR = 0.22; 95% confidence interval = 0.07–0.79;
P = 0.02). The double heterozygote variants of two ET-1 gene polymorphisms were associated with significantly less risk for chronic heart failure with higher levels of big endothelin.</description><identifier>ISSN: 0014-4800</identifier><identifier>EISSN: 1096-0945</identifier><identifier>DOI: 10.1006/exmp.2002.2453</identifier><identifier>PMID: 12565798</identifier><identifier>CODEN: EXMPA6</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; big endothelin ; Biological and medical sciences ; BMI ; Cardiac Output, Low - metabolism ; Cardiology. Vascular system ; chronic heart failure ; Endothelin-1 - genetics ; Endothelin-1 - metabolism ; endothelin-1-gene polymorphism ; Endothelins - blood ; Female ; Genotype ; Heart ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Humans ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Genetic ; Protein Precursors - blood ; Protein Precursors - genetics ; Protein Precursors - metabolism ; Risk Factors</subject><ispartof>Experimental and molecular pathology, 2002-12, Vol.73 (3), p.230-233</ispartof><rights>2002 Elsevier Science (USA)</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-50eaa1ab61d6baae843e9a2e5cee1215a4f30cd87ccd3f268c8fbf2883adab2a3</citedby><cites>FETCH-LOGICAL-c436t-50eaa1ab61d6baae843e9a2e5cee1215a4f30cd87ccd3f268c8fbf2883adab2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/exmp.2002.2453$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14022687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12565798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vašků, A.</creatorcontrib><creatorcontrib>Špinarová, L.</creatorcontrib><creatorcontrib>Goldbergová, M.</creatorcontrib><creatorcontrib>Mužik, J.</creatorcontrib><creatorcontrib>Špinar, J.</creatorcontrib><creatorcontrib>Vı&#x0301;tovec, J.</creatorcontrib><creatorcontrib>Toman, J.</creatorcontrib><creatorcontrib>Vácha, J.</creatorcontrib><title>The Double Heterozygote of Two Endothelin-1 Gene Polymorphisms (G8002A and -3A/-4A) Is Related to Big Endothelin Levels in Chronic Heart Failure</title><title>Experimental and molecular pathology</title><addtitle>Exp Mol Pathol</addtitle><description>The aim of this study was to focus on the relationship among the associated genotypes of G (8002) A and -3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/or biochemical parameters in Czech (Caucasian) patients with chronic heart failure. Included in the study were 103 patients with chronic heart failure (functional classes NYHA II–IV, ejection fraction <40%). The ET-1 gene polymorphisms were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism methods. A significant decrease in the ET-1-associated genotype AG3A4A number (double heterozygote) was observed in CHF patients with plasma big endothelin levels above 0.7 pmol/L compared to those with levels below 0.7 pmol/L (OR = 0.19; 95% confidence interval = 0.06–0.57;
P = 0.005;
P
corr = 0.03). We found a significant decrease in the AG3A4A genotype number in the other groups compared to the group of patients with both big endothelin and endothelin-1 levels under 0.7 pmol/L (OR = 0.22; 95% confidence interval = 0.07–0.79;
P = 0.02). The double heterozygote variants of two ET-1 gene polymorphisms were associated with significantly less risk for chronic heart failure with higher levels of big endothelin.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>big endothelin</subject><subject>Biological and medical sciences</subject><subject>BMI</subject><subject>Cardiac Output, Low - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>chronic heart failure</subject><subject>Endothelin-1 - genetics</subject><subject>Endothelin-1 - metabolism</subject><subject>endothelin-1-gene polymorphism</subject><subject>Endothelins - blood</subject><subject>Female</subject><subject>Genotype</subject><subject>Heart</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Protein Precursors - blood</subject><subject>Protein Precursors - genetics</subject><subject>Protein Precursors - metabolism</subject><subject>Risk Factors</subject><issn>0014-4800</issn><issn>1096-0945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUGP0zAQhSMEYsvClSPyBQSHdMd2kjrHUna7K1UCoXK2JvZka-TExU4Wyq_gJ5OqlZYLp5nDN2-e3suy1xzmHKC6ol_dfi4AxFwUpXySzTjUVQ51UT7NZgC8yAsFcJG9SOk7ANTAxfPsgouyKhe1mmV_tjtin8LYeGK3NFAMvw_3YSAWWrb9Gdh1b8OwI-_6nLM19cS-BH_oQtzvXOoSe7-e5MWSYW9ZLpdXebH8wO4S-0oeB7JsCOyju_9Hhm3ogXxi07baxdA7M_3FOLAbdH6M9DJ71qJP9Oo8L7NvN9fb1W2--by-Wy03uSlkNeQlECLHpuK2ahBJFZJqFFQaIi54iUUrwVi1MMbKVlTKqLZphVISLTYC5WX27qS7j-HHSGnQnUuGvMeewpj0QihZg6wmcH4CTQwpRWr1ProO40Fz0McO9LEDfexAHzuYDt6clcemI_uIn0OfgLdnAJNB30bsjUuPXAFiMryYOHXiprzowVHUyTjqDVkXyQzaBvc_D38B1heiVg</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Vašků, A.</creator><creator>Špinarová, L.</creator><creator>Goldbergová, M.</creator><creator>Mužik, J.</creator><creator>Špinar, J.</creator><creator>Vı&#x0301;tovec, J.</creator><creator>Toman, J.</creator><creator>Vácha, J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>The Double Heterozygote of Two Endothelin-1 Gene Polymorphisms (G8002A and -3A/-4A) Is Related to Big Endothelin Levels in Chronic Heart Failure</title><author>Vašků, A. ; Špinarová, L. ; Goldbergová, M. ; Mužik, J. ; Špinar, J. ; Vı&#x0301;tovec, J. ; Toman, J. ; Vácha, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-50eaa1ab61d6baae843e9a2e5cee1215a4f30cd87ccd3f268c8fbf2883adab2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>big endothelin</topic><topic>Biological and medical sciences</topic><topic>BMI</topic><topic>Cardiac Output, Low - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>chronic heart failure</topic><topic>Endothelin-1 - genetics</topic><topic>Endothelin-1 - metabolism</topic><topic>endothelin-1-gene polymorphism</topic><topic>Endothelins - blood</topic><topic>Female</topic><topic>Genotype</topic><topic>Heart</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Protein Precursors - blood</topic><topic>Protein Precursors - genetics</topic><topic>Protein Precursors - metabolism</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vašků, A.</creatorcontrib><creatorcontrib>Špinarová, L.</creatorcontrib><creatorcontrib>Goldbergová, M.</creatorcontrib><creatorcontrib>Mužik, J.</creatorcontrib><creatorcontrib>Špinar, J.</creatorcontrib><creatorcontrib>Vı&#x0301;tovec, J.</creatorcontrib><creatorcontrib>Toman, J.</creatorcontrib><creatorcontrib>Vácha, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and molecular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vašků, A.</au><au>Špinarová, L.</au><au>Goldbergová, M.</au><au>Mužik, J.</au><au>Špinar, J.</au><au>Vı&#x0301;tovec, J.</au><au>Toman, J.</au><au>Vácha, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Double Heterozygote of Two Endothelin-1 Gene Polymorphisms (G8002A and -3A/-4A) Is Related to Big Endothelin Levels in Chronic Heart Failure</atitle><jtitle>Experimental and molecular pathology</jtitle><addtitle>Exp Mol Pathol</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>73</volume><issue>3</issue><spage>230</spage><epage>233</epage><pages>230-233</pages><issn>0014-4800</issn><eissn>1096-0945</eissn><coden>EXMPA6</coden><abstract>The aim of this study was to focus on the relationship among the associated genotypes of G (8002) A and -3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/or biochemical parameters in Czech (Caucasian) patients with chronic heart failure. Included in the study were 103 patients with chronic heart failure (functional classes NYHA II–IV, ejection fraction <40%). The ET-1 gene polymorphisms were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism methods. A significant decrease in the ET-1-associated genotype AG3A4A number (double heterozygote) was observed in CHF patients with plasma big endothelin levels above 0.7 pmol/L compared to those with levels below 0.7 pmol/L (OR = 0.19; 95% confidence interval = 0.06–0.57;
P = 0.005;
P
corr = 0.03). We found a significant decrease in the AG3A4A genotype number in the other groups compared to the group of patients with both big endothelin and endothelin-1 levels under 0.7 pmol/L (OR = 0.22; 95% confidence interval = 0.07–0.79;
P = 0.02). The double heterozygote variants of two ET-1 gene polymorphisms were associated with significantly less risk for chronic heart failure with higher levels of big endothelin.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>12565798</pmid><doi>10.1006/exmp.2002.2453</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4800 |
| ispartof | Experimental and molecular pathology, 2002-12, Vol.73 (3), p.230-233 |
| issn | 0014-4800 1096-0945 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72839036 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Aged, 80 and over big endothelin Biological and medical sciences BMI Cardiac Output, Low - metabolism Cardiology. Vascular system chronic heart failure Endothelin-1 - genetics Endothelin-1 - metabolism endothelin-1-gene polymorphism Endothelins - blood Female Genotype Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Male Medical sciences Middle Aged Polymorphism, Genetic Protein Precursors - blood Protein Precursors - genetics Protein Precursors - metabolism Risk Factors |
| title | The Double Heterozygote of Two Endothelin-1 Gene Polymorphisms (G8002A and -3A/-4A) Is Related to Big Endothelin Levels in Chronic Heart Failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T03%3A41%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Double%20Heterozygote%20of%20Two%20Endothelin-1%20Gene%20Polymorphisms%20(G8002A%20and%20-3A/-4A)%20Is%20Related%20to%20Big%20Endothelin%20Levels%20in%20Chronic%20Heart%20Failure&rft.jtitle=Experimental%20and%20molecular%20pathology&rft.au=Va%C5%A1k%C5%AF,%20A.&rft.date=2002-12-01&rft.volume=73&rft.issue=3&rft.spage=230&rft.epage=233&rft.pages=230-233&rft.issn=0014-4800&rft.eissn=1096-0945&rft.coden=EXMPA6&rft_id=info:doi/10.1006/exmp.2002.2453&rft_dat=%3Cproquest_cross%3E72839036%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72839036&rft_id=info:pmid/12565798&rft_els_id=S0014480002924536&rfr_iscdi=true |