The Double Heterozygote of Two Endothelin-1 Gene Polymorphisms (G8002A and -3A/-4A) Is Related to Big Endothelin Levels in Chronic Heart Failure

The aim of this study was to focus on the relationship among the associated genotypes of G (8002) A and -3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/or biochemical parameters in Czech (Caucasian) patients with chronic heart failure. Included in the study were 103 patients wit...

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Veröffentlicht in:	Experimental and molecular pathology 2002-12, Vol.73 (3), p.230-233
Hauptverfasser:	Vašků, A., Špinarová, L., Goldbergová, M., Mužik, J., Špinar, J., Vı&#x0301, tovec, J., Toman, J., Vácha, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over big endothelin Biological and medical sciences BMI Cardiac Output, Low - metabolism Cardiology. Vascular system chronic heart failure Endothelin-1 - genetics Endothelin-1 - metabolism endothelin-1-gene polymorphism Endothelins - blood Female Genotype Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Male Medical sciences Middle Aged Polymorphism, Genetic Protein Precursors - blood Protein Precursors - genetics Protein Precursors - metabolism Risk Factors
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Zusammenfassung:	The aim of this study was to focus on the relationship among the associated genotypes of G (8002) A and -3A/-4A endothelin-1 (ET-1) gene polymorphisms and some clinical and/or biochemical parameters in Czech (Caucasian) patients with chronic heart failure. Included in the study were 103 patients with chronic heart failure (functional classes NYHA II–IV, ejection fraction
ISSN:	0014-4800 1096-0945
DOI:	10.1006/exmp.2002.2453