Interaction of cholesterol-conjugated alkylating oligonucleotide derivatives with cellular biopolymers

Interactions of oligonucleotide derivatives with mammalian cells and cellular biopolymers have been investigated. The derivatives were oligonucleotides bearing an alkylating 2-chloroethylamino group at the 3′-end and a cholesterol residue at the 5′-terminal phosphate. These compounds are readily tak...

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Veröffentlicht in:	FEBS letters 1992-03, Vol.299 (2), p.124-126
Hauptverfasser:	Ryte, A.S., Karamyshev, V.N., Nechaeva, M.V., Guskova, Z.V., Ivanova, E.M., Zarytova, V.F., Vlassov, V.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity modification Alkylation Ascites - metabolism Autoradiography Biological and medical sciences Biopolymers Cell Line Cell physiology Cellular uptake Cholesterol - metabolism DNA - metabolism Electrophoresis, Polyacrylamide Gel Endocytosis Fundamental and applied biological sciences. Psychology Molecular and cellular biology Oligonucleotide derivative Oligonucleotides - metabolism Proteins - metabolism RNA - metabolism Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Interactions of oligonucleotide derivatives with mammalian cells and cellular biopolymers have been investigated. The derivatives were oligonucleotides bearing an alkylating 2-chloroethylamino group at the 3′-end and a cholesterol residue at the 5′-terminal phosphate. These compounds are readily taken up by cells and react with cellular DNA, RNA and some proteins which may play a role in delivery of the compounds into cells.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(92)80229-A