Induction of Mn-superoxide dismutase by Tumor Necrosis Factor, Interleukin-1 and Interleukin-6 in human hepatoma cells

Effects of Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of Mn-superoxide dismutase (Mn-SOD) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1. Both TNF...

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Veröffentlicht in:	Biochemical and biophysical research communications 1992-02, Vol.182 (3), p.1100-1107
Hauptverfasser:	Ono, Minoru, Kohda, Hironobu, Kawaguchi, Tetsuo, Ohhira, Motoyuki, Sekiya, Chihiro, Namiki, Masayoshi, Takeyasu, Akira, Taniguchi, Naoyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biological and medical sciences Carcinoma, Hepatocellular Cell Division - drug effects Cell Line Cell physiology DNA Replication - drug effects Enzyme Induction Fundamental and applied biological sciences. Psychology Humans Interferon-gamma - pharmacology Interleukin-1 - pharmacology Interleukin-6 - pharmacology Kinetics Liver Neoplasms Molecular and cellular biology Recombinant Proteins - pharmacology Responses to growth factors, tumor promotors, other factors Superoxide Dismutase - biosynthesis Thymidine - metabolism Tumor Necrosis Factor-alpha - pharmacology
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Zusammenfassung:	Effects of Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of Mn-superoxide dismutase (Mn-SOD) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1. Both TNF and IL-1 enhanced the Mn-SOD production to the level of 30- to 40-fold. IL-6 also increased the enzyme protein to 2- to 3-fold of the basal level without any cell proliferative effect. A specific antibody against IL-6 almost completely inhibited the induction of Mn-SOD. IL-6, as well as TNF and IL-1, appears to play some role in the Mn-SOD protein expression in human hepatoma cells.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(92)91845-H