Microwave irradiation and cross-linking of collagen

In a multifactorial experiment, dermal sheep collagen was treated in diluted glutaraldehyde solutions, 70% ethyl alcohol, Cialit 1:5000, and distilled water for 1, 3 and 5 min, respectively, in combination with microwave irradiation at different temperature settings. The shrinkage temperature indica...

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Veröffentlicht in:Biomaterials 1992, Vol.13 (1), p.34-37
Hauptverfasser: Visser, C.E., Voute, A.B.E., Oosting, J., Boon, M.E., Kok, L.P.
Format: Artikel
Sprache:eng
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Zusammenfassung:In a multifactorial experiment, dermal sheep collagen was treated in diluted glutaraldehyde solutions, 70% ethyl alcohol, Cialit 1:5000, and distilled water for 1, 3 and 5 min, respectively, in combination with microwave irradiation at different temperature settings. The shrinkage temperature indicating the degree of cross-linking achieved was then determined. Treatment in 0.65% glutaraldehyde with microwave irradiation setting for 60°C resulted in the maximum shrinkage temperature within 1 min, whilst at the lower setting of 50°C the maximum shrinkage temperature for both glutaraldehyde solutions is only reached after 5 min. Neither microwave irradiation by itself, Cialit or ethyl alcohol induce cross-linking of collagen fibres. These findings are relevant for implant studies.
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(92)90092-3