Stimulatory effect of free fatty acids on growth hormone releasing hormone secretion by fetal rat neurons in monolayer culture

The effects of free fatty acids (FFAs) on growth hormone releasing hormone (GHRH) secretion by fetal rat cortical and hypothalamic neurons in monolayer culture have been investigated. Treatment with caprylic or oleic acids for 90 min, induced a dose-dependent increase in GHRH secretion. The stimulat...

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Veröffentlicht in:	Neuroscience letters 1992-01, Vol.135 (1), p.80-82
Hauptverfasser:	Señaris, Rosa M., Lewis, Mark D., Lago, Francisca, Dominguez, Fernando, Scanlon, Maurice F., Dieguez, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcimycin - pharmacology Caprylates - pharmacology Cells, Cultured Cerebral Cortex - metabolism Dose-Response Relationship, Drug Fetal rat cortical cell culture Fetal rat hypothalamic cell culture Fetus Free fatty acid Fundamental and applied biological sciences. Psychology Growth hormone releasing hormone Growth Hormone-Releasing Hormone - metabolism Hormones and neuropeptides. Regulation Hypothalamus - metabolism Hypothalamus. Hypophysis. Epiphysis. Urophysis Kinetics Neurons - drug effects Neurons - metabolism Potassium Chloride - pharmacology Rats Vertebrates: endocrinology
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Zusammenfassung:	The effects of free fatty acids (FFAs) on growth hormone releasing hormone (GHRH) secretion by fetal rat cortical and hypothalamic neurons in monolayer culture have been investigated. Treatment with caprylic or oleic acids for 90 min, induced a dose-dependent increase in GHRH secretion. The stimulatory effect of caprylic acid was time-dependent, being present after 90 min and 5 h but not after 24 h. Finally, GHRH release induced by 56 mM KCl or by the calcium ionophore A23187 was not modified by 5×10 −3 M caprylic acid. These data support a role for FFAs on GHRH secretion.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(92)90140-3