Identification of 2α-hydroxy-4-pregnene-3,20-dione in human pregnancy urine

2α-Hydroxyprogesterone (2α-hydroxy-4-pregnene-3,20-dione) was identified in human late pregnancy urine by liquid-gel chromatography, GLC and GC-MS. In addition, the following 2-hydroxylated C 21 steroids were found and identified as 2ξ-hydroxy-5ξ-pregnane-3,20-dione, 2ξ,20ξ-dihydroxy-4-pregnen-3-one...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 1992-02, Vol.41 (2), p.191-196
Hauptverfasser:	Colombier, M., Gachancard-Bouya, J.-L.J., Bègue, R.-J., Prost, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, Gel Female Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry Hormone metabolism and regulation Humans Hydroxyprogesterones - urine Pregnancy Pregnancy. Parturition. Lactation Vertebrates: reproduction
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Beschreibung
Zusammenfassung:	2α-Hydroxyprogesterone (2α-hydroxy-4-pregnene-3,20-dione) was identified in human late pregnancy urine by liquid-gel chromatography, GLC and GC-MS. In addition, the following 2-hydroxylated C 21 steroids were found and identified as 2ξ-hydroxy-5ξ-pregnane-3,20-dione, 2ξ,20ξ-dihydroxy-4-pregnen-3-one, 2α,3α-dihydroxy-5α- (and 5β)-pregnan-20-one, two isomers of pregnane-2,3,20-triol and 2ξ,3ξ,16ξ-trihydroxy-5ξ-pregnan-20-one.
ISSN:	0960-0760 1879-1220
DOI:	10.1016/0960-0760(92)90048-N