Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells
Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells...
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| Veröffentlicht in: | Acta biochimica polonica 2002-01, Vol.49 (4), p.1005-1012 |
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| container_title | Acta biochimica polonica |
| container_volume | 49 |
| creator | Nosach, Lidiya Dyachenko, Nataliya Zhovnovataya, Valentina Lozinskiy, Miron Lozitsky, Victor |
| description | Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction. |
| doi_str_mv | 10.18388/abp.2002_3760 |
| format | Article |
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The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. 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The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.</description><subject>4-Aminobenzoic Acid - pharmacology</subject><subject>Adenoviruses, Human - drug effects</subject><subject>Adenoviruses, Human - metabolism</subject><subject>Adenoviruses, Human - physiology</subject><subject>Aminocaproic Acid - pharmacology</subject><subject>Antiviral Agents - pharmacology</subject><subject>Cell Line, Tumor</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Humans</subject><subject>Protein Processing, Post-Translational - drug effects</subject><subject>Viral Proteins - metabolism</subject><subject>Virion - drug effects</subject><subject>Virion - metabolism</subject><subject>Virus Assembly - drug effects</subject><issn>0001-527X</issn><issn>1734-154X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYMotla3LmVW7qbm2UmWUnwUCm4Uuhvy1MhMMk5mhC7956a21MXlXjjfuRwOANcIzhEnnN9J1c0xhLgm1QKegCmqCC0Ro5tTMIUQopLhajMBFyl9ZoogQc_BBGFGGYbVFPyswodXfvAxFNEVXR8HG5vt4PXu1jYlH953ijQ2xG_fy2YP-ZAKtS1sl3wTQylbH6KWWcpOqb0pZMjTKhvGtvDh6B9T6YOzerCm0LZp0iU4c7JJ9uqwZ-Dt8eF1-VyuX55Wy_t1qbFAQ4kFhNIYYZWkFCLKhYSCcEoxsZAYZZh2TjCuhXTYMoYUNJK5LPGqQo6QGbjd_80Zv0abhrr1aZdABhvHVFeY42ohYAbne1D3MaXeurrrfSv7bY1g_Vd6nUuvj6Vnw83h86haa_7xQ8vkF0DegQY</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Nosach, Lidiya</creator><creator>Dyachenko, Nataliya</creator><creator>Zhovnovataya, Valentina</creator><creator>Lozinskiy, Miron</creator><creator>Lozitsky, Victor</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells</title><author>Nosach, Lidiya ; Dyachenko, Nataliya ; Zhovnovataya, Valentina ; Lozinskiy, Miron ; Lozitsky, Victor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-2900add9eba4401489a09384423e03dbd5cff958c9af2e551b0da5f03d8771f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>4-Aminobenzoic Acid - pharmacology</topic><topic>Adenoviruses, Human - drug effects</topic><topic>Adenoviruses, Human - metabolism</topic><topic>Adenoviruses, Human - physiology</topic><topic>Aminocaproic Acid - pharmacology</topic><topic>Antiviral Agents - pharmacology</topic><topic>Cell Line, Tumor</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Humans</topic><topic>Protein Processing, Post-Translational - drug effects</topic><topic>Viral Proteins - metabolism</topic><topic>Virion - drug effects</topic><topic>Virion - metabolism</topic><topic>Virus Assembly - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nosach, Lidiya</creatorcontrib><creatorcontrib>Dyachenko, Nataliya</creatorcontrib><creatorcontrib>Zhovnovataya, Valentina</creatorcontrib><creatorcontrib>Lozinskiy, Miron</creatorcontrib><creatorcontrib>Lozitsky, Victor</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biochimica polonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nosach, Lidiya</au><au>Dyachenko, Nataliya</au><au>Zhovnovataya, Valentina</au><au>Lozinskiy, Miron</au><au>Lozitsky, Victor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells</atitle><jtitle>Acta biochimica polonica</jtitle><addtitle>Acta Biochim Pol</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>49</volume><issue>4</issue><spage>1005</spage><epage>1012</epage><pages>1005-1012</pages><issn>0001-527X</issn><eissn>1734-154X</eissn><abstract>Maturation of adenovirus particles is markedly affected by proteolytic processing. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | 4-Aminobenzoic Acid - pharmacology Adenoviruses, Human - drug effects Adenoviruses, Human - metabolism Adenoviruses, Human - physiology Aminocaproic Acid - pharmacology Antiviral Agents - pharmacology Cell Line, Tumor Electrophoresis, Polyacrylamide Gel Humans Protein Processing, Post-Translational - drug effects Viral Proteins - metabolism Virion - drug effects Virion - metabolism Virus Assembly - drug effects |
| title | Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells |
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