Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells

Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells...

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Veröffentlicht in:	Acta biochimica polonica 2002-01, Vol.49 (4), p.1005-1012
Hauptverfasser:	Nosach, Lidiya, Dyachenko, Nataliya, Zhovnovataya, Valentina, Lozinskiy, Miron, Lozitsky, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobenzoic Acid - pharmacology Adenoviruses, Human - drug effects Adenoviruses, Human - metabolism Adenoviruses, Human - physiology Aminocaproic Acid - pharmacology Antiviral Agents - pharmacology Cell Line, Tumor Electrophoresis, Polyacrylamide Gel Humans Protein Processing, Post-Translational - drug effects Viral Proteins - metabolism Virion - drug effects Virion - metabolism Virus Assembly - drug effects
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Zusammenfassung:	Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.
ISSN:	0001-527X 1734-154X
DOI:	10.18388/abp.2002_3760