NO-inhibiting and vasotropic activity of some compounds with thioamidine group
Using the method of electron paramagnetic spectroscopy we demonstrated that thiazine-thiazoline compounds and aminoethyl isothiourea containing the thioamidine group inhibit NO production in the liver of endotoxin-treated mice. Injection of these agents to anesthetized rats increased arterial pressu...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2002-10, Vol.134 (4), p.338-341 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 134 |
| creator | Proskuryakov, S Ya Kucherenko, N G Trishkina, A I Filimonova, M V Shevchuk, A G Shtein, L V Verkhovskii, Yu G Konoplyannikov, A G Mandrugin, A A Fedoseev, V M Skvortsov, V G |
| description | Using the method of electron paramagnetic spectroscopy we demonstrated that thiazine-thiazoline compounds and aminoethyl isothiourea containing the thioamidine group inhibit NO production in the liver of endotoxin-treated mice. Injection of these agents to anesthetized rats increased arterial pressure and enhanced respiration rate. This effect probably reflects inhibition of not only inducible, but also the constitutive synthesis of NO by compounds with thioamidine group. |
| doi_str_mv | 10.1023/A:1021943811672 |
| format | Article |
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Injection of these agents to anesthetized rats increased arterial pressure and enhanced respiration rate. 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| subjects | Animals Blood Pressure - drug effects Dose-Response Relationship, Drug Endotoxins Enzyme Inhibitors - pharmacology Liver - drug effects Liver - enzymology Male Mice Nitric Oxide - antagonists & inhibitors Nitric Oxide Synthase - antagonists & inhibitors Rats Rats, Wistar Respiration - drug effects Species Specificity Thiazines - pharmacology Thiazoles - pharmacology Vasoconstrictor Agents - pharmacology |
| title | NO-inhibiting and vasotropic activity of some compounds with thioamidine group |
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