NO-inhibiting and vasotropic activity of some compounds with thioamidine group

Using the method of electron paramagnetic spectroscopy we demonstrated that thiazine-thiazoline compounds and aminoethyl isothiourea containing the thioamidine group inhibit NO production in the liver of endotoxin-treated mice. Injection of these agents to anesthetized rats increased arterial pressu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2002-10, Vol.134 (4), p.338-341
Hauptverfasser:	Proskuryakov, S Ya, Kucherenko, N G, Trishkina, A I, Filimonova, M V, Shevchuk, A G, Shtein, L V, Verkhovskii, Yu G, Konoplyannikov, A G, Mandrugin, A A, Fedoseev, V M, Skvortsov, V G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Dose-Response Relationship, Drug Endotoxins Enzyme Inhibitors - pharmacology Liver - drug effects Liver - enzymology Male Mice Nitric Oxide - antagonists & inhibitors Nitric Oxide Synthase - antagonists & inhibitors Rats Rats, Wistar Respiration - drug effects Species Specificity Thiazines - pharmacology Thiazoles - pharmacology Vasoconstrictor Agents - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Using the method of electron paramagnetic spectroscopy we demonstrated that thiazine-thiazoline compounds and aminoethyl isothiourea containing the thioamidine group inhibit NO production in the liver of endotoxin-treated mice. Injection of these agents to anesthetized rats increased arterial pressure and enhanced respiration rate. This effect probably reflects inhibition of not only inducible, but also the constitutive synthesis of NO by compounds with thioamidine group.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1021943811672