Fetal microchimerism in patients with primary biliary cirrhosis

Fetal microchimerism in patients with primary biliary cirrhosis

Fetal microchimerism (FM) has been implicated in the pathogenesis of primary biliary cirrhosis (PBC). The aim of the study was to investigate the presence of FM in PBC patients. FM was studied in 28 women, 14 with PBC and 14 healthy controls.DNA was extracted from peripheral blood cells, and a PCR a...

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Veröffentlicht in:Medicina clínica 2002-12, Vol.119 (20), p.770-772
Hauptverfasser: Selva O'Callaghan, Albert, Balada Prades, Eva, Castells Fusté, Lluís, Vargas Blasco, Víctor, Solans Laque, Roser, Vilardell Tarrés, Miquel
Format: Artikel
Sprache:spa
Schlagworte:
Adult
Aged
Chromosomes, Human, Y - genetics
DNA - blood
Female
Fetus - cytology
Humans
Liver Cirrhosis, Biliary - blood
Liver Cirrhosis, Biliary - etiology
Middle Aged
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Zusammenfassung:Fetal microchimerism (FM) has been implicated in the pathogenesis of primary biliary cirrhosis (PBC). The aim of the study was to investigate the presence of FM in PBC patients. FM was studied in 28 women, 14 with PBC and 14 healthy controls.DNA was extracted from peripheral blood cells, and a PCR analysis to detect a specific Y-chromosome sequence was performed. Specificity was confirmed by Southern-blot analysis. The Y-chromosome sequence was amplified from peripheral-blood cell DNA in only one PBC patient and in none of the controls. FM does not seem to play a major role in patients with PBC.
ISSN:0025-7753
DOI:10.1016/S0025-7753(02)73575-6