Developmental modulation of myocardial mechanics: Age- and growth-related alterations in afterload and contractility

Somatic growth is associated with alterations in myocardial mechanics in children with heart disease and in most animal models of congenital heart disease. However, the effect of age and body size on myocardial contractility and loading conditions in normal infants and children is not known. Therefo...

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Veröffentlicht in:	Journal of the American College of Cardiology 1992-03, Vol.19 (3), p.619-629
Hauptverfasser:	Colan, Steven D., Parness, Ira A., Spevak, Philip J., Sanders, Stephen P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aging - physiology Biological and medical sciences Blood Pressure - physiology Cardiovascular system Child Child, Preschool Echocardiography Female Heart - growth & development Heart - physiology Heart Ventricles - anatomy & histology Humans Infant Investigative techniques of hemodynamics Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Myocardial Contraction - physiology Stress, Mechanical Stroke Volume - physiology Ventricular Function, Left - physiology
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Beschreibung
Zusammenfassung:	Somatic growth is associated with alterations in myocardial mechanics in children with heart disease and in most animal models of congenital heart disease. However, the effect of age and body size on myocardial contractility and loading conditions in normal infants and children is not known. Therefore, 256 normal children aged 7 days to 19 years (34%
ISSN:	0735-1097 1558-3597
DOI:	10.1016/S0735-1097(10)80282-7