Antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, thaliblastine, on two human glioma cell lines

Antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, thaliblastine, on two human glioma cell lines

The antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, Thaliblastine, on two human glioma cell lines is described. Thaliblastine was added once one day following start of culture; proliferation was monitored over 7 days. The antiproliferative activity of Thaliblastine...

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Veröffentlicht in:Journal of cancer research and clinical oncology 1992-02, Vol.118 (2), p.83-86
Hauptverfasser: TODOROV, D. K, ZELLER, W. J
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic agents
Aporphines - administration & dosage
Aporphines - pharmacology
Biological and medical sciences
Chemotherapy
Drug Screening Assays, Antitumor
Glioma - drug therapy
Humans
Medical sciences
Pharmacology. Drug treatments
Tumor Cells, Cultured - drug effects
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creator TODOROV, D. K
ZELLER, W. J
description The antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, Thaliblastine, on two human glioma cell lines is described. Thaliblastine was added once one day following start of culture; proliferation was monitored over 7 days. The antiproliferative activity of Thaliblastine was strongly dependent on concentration and time of incubation. The ID50 of Thaliblastine in T406 and GW27 glioma lines was 5.1 micrograms/ml and 8.2 micrograms/ml (7.0 microM and 11.2 microM), respectively.
doi_str_mv 10.1007/BF01187497
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source MEDLINE; Springer Nature - Complete Springer Journals
subjects Antineoplastic agents
Aporphines - administration & dosage
Aporphines - pharmacology
Biological and medical sciences
Chemotherapy
Drug Screening Assays, Antitumor
Glioma - drug therapy
Humans
Medical sciences
Pharmacology. Drug treatments
Tumor Cells, Cultured - drug effects
title Antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, thaliblastine, on two human glioma cell lines
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