Antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, thaliblastine, on two human glioma cell lines

The antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, Thaliblastine, on two human glioma cell lines is described. Thaliblastine was added once one day following start of culture; proliferation was monitored over 7 days. The antiproliferative activity of Thaliblastine...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cancer research and clinical oncology 1992-02, Vol.118 (2), p.83-86
Hauptverfasser:	TODOROV, D. K, ZELLER, W. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Aporphines - administration & dosage Aporphines - pharmacology Biological and medical sciences Chemotherapy Drug Screening Assays, Antitumor Glioma - drug therapy Humans Medical sciences Pharmacology. Drug treatments Tumor Cells, Cultured - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, Thaliblastine, on two human glioma cell lines is described. Thaliblastine was added once one day following start of culture; proliferation was monitored over 7 days. The antiproliferative activity of Thaliblastine was strongly dependent on concentration and time of incubation. The ID50 of Thaliblastine in T406 and GW27 glioma lines was 5.1 micrograms/ml and 8.2 micrograms/ml (7.0 microM and 11.2 microM), respectively.
ISSN:	0171-5216 1432-1335
DOI:	10.1007/BF01187497