Effect of configuration of muramyl dipeptide glycoside bond and structure of glycoside aglycon on their capacity to stimulate production of interleukin-1 and tumor necrosis factor by macrophages

Effects of 11 original glycoside derivatives of muramyl dipeptide on the production of interleukin-1 and tumor necrosis factor by mouse peritoneal macrophages were studied. The relationship between macrophage activation evaluated by induction of these cytokines and configuration of glycoside bond an...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2002-09, Vol.134 (3), p.281-283
Hauptverfasser:	Kalyuzhin, O V, Nelyubov, M V, Kalyuzhina, E V, Kuzovlev, F N, Shkalev, M V
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylmuramyl-Alanyl-Isoglutamine - chemistry Adjuvants, Immunologic - chemistry Animals Cells, Cultured Dose-Response Relationship, Drug Glycosides - chemistry Interleukin-1 - biosynthesis Interleukin-1 - metabolism Lipopolysaccharides - metabolism Macrophages - metabolism Macrophages, Peritoneal - metabolism Mice Mice, Inbred C57BL Tumor Necrosis Factor-alpha - biosynthesis
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Zusammenfassung:	Effects of 11 original glycoside derivatives of muramyl dipeptide on the production of interleukin-1 and tumor necrosis factor by mouse peritoneal macrophages were studied. The relationship between macrophage activation evaluated by induction of these cytokines and configuration of glycoside bond and aglycon structure of MDP was revealed.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1021519921125