Circulating highly fluorescent reticulocytes to predict the adequate harvesting of peripheral blood progenitor cells in platinum-based chemotherapy
We prospectively evaluated whether peripheral blood progenitor cells (PBPC) yield from a single leukapheresis could be predicted by measurement of circulating highly fluorescent reticulocytes (HFR). PBPC were collected from 46 leukaphereses in 15 patients with gynecological cancer following platinum...
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| Veröffentlicht in: | Transfusion and apheresis science 2002-12, Vol.27 (3), p.199-202 |
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| container_title | Transfusion and apheresis science |
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| creator | Kurata, H Takakuwa, K Tsuneki, I Aoki, Y Tanaka, K |
| description | We prospectively evaluated whether peripheral blood progenitor cells (PBPC) yield from a single leukapheresis could be predicted by measurement of circulating highly fluorescent reticulocytes (HFR). PBPC were collected from 46 leukaphereses in 15 patients with gynecological cancer following platinum-based chemotherapy. Once a level of at least 5.0% HFR was achieved, sufficient PBPC were collected in a single harvest in 71% of the procedures. Whereas, failure to mobilize sufficient PBPC occurred in 24 of 28 leukaphereses when the percentage of circulating HFR was less than 5.0%. In conclusion, circulating HFR may aid in the efficiency of PBPC collections in platinum-based chemotherapy. |
| doi_str_mv | 10.1016/S1473-0502(02)00065-4 |
| format | Article |
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PBPC were collected from 46 leukaphereses in 15 patients with gynecological cancer following platinum-based chemotherapy. Once a level of at least 5.0% HFR was achieved, sufficient PBPC were collected in a single harvest in 71% of the procedures. Whereas, failure to mobilize sufficient PBPC occurred in 24 of 28 leukaphereses when the percentage of circulating HFR was less than 5.0%. 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In conclusion, circulating HFR may aid in the efficiency of PBPC collections in platinum-based chemotherapy.</description><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Benzophenoneidum</subject><subject>CD34+ cells</subject><subject>CFU-GM</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fluorescent Dyes</subject><subject>Fluorometry</subject><subject>Genital Neoplasms, Female - blood</subject><subject>Genital Neoplasms, Female - drug therapy</subject><subject>Genital Neoplasms, Female - therapy</subject><subject>Graft Survival</subject><subject>Health technology assessment</subject><subject>Hematopoietic Stem Cell Mobilization</subject><subject>HFR</subject><subject>Humans</subject><subject>Leukapheresis</subject><subject>Middle Aged</subject><subject>Organoplatinum Compounds - administration & dosage</subject><subject>PBPC</subject><subject>Peripheral Blood Stem Cell Transplantation - methods</subject><subject>Platinum-based chemotherapy</subject><subject>Prospective Studies</subject><subject>Receptors, Complement 3b - analysis</subject><subject>Reticulocyte Count</subject><issn>1473-0502</issn><issn>1878-1683</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1r3DAUFKWhSdP-hBadSnpw-2RbtnwqYekXBHpoexay9LRWsS1HkgP7O_KHI-9u6bEgkODNvBnNEPKGwQcGrPn4k9VtVQCH8gbK9wDQ8KJ-Rq6YaEXBGlE9z--_kEvyMsY_AKxlXfOCXLKSQ1ey6oo87lzQ66iSm_d0cPthPFA7rj5g1DgnGjC5PPf6kDDS5OkS0DidaBqQKoP3q0pIBxUeMB53eEsXDG4ZMKiR9qP3JnP8HmeXfKAaxzFSN9PlqLlORa8iGqoHnHzaSMvhFbmwaoz4-nxfk99fPv_afSvufnz9vru9K3TVsFTUrIZeidZYrXoLVmCrARRwxkuje1sxFJ3lhhkUpm9VycvedLqta8FVbWx1Td6d9mZ_92v2LycXN4NqRr9G2ZYCBO9YBvITUAcfY0Arl-AmFQ6SgdzakMc25Ba13M7Whqwz7-1ZYO0nNP9Y5_gz4NMJgPmbDw6DjNrhrHPEAXWSxrv_SDwBfzWfIw</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Kurata, H</creator><creator>Takakuwa, K</creator><creator>Tsuneki, I</creator><creator>Aoki, Y</creator><creator>Tanaka, K</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Circulating highly fluorescent reticulocytes to predict the adequate harvesting of peripheral blood progenitor cells in platinum-based chemotherapy</title><author>Kurata, H ; 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| ispartof | Transfusion and apheresis science, 2002-12, Vol.27 (3), p.199-202 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Benzophenoneidum CD34+ cells CFU-GM Combined Modality Therapy Female Flow Cytometry Fluorescent Dyes Fluorometry Genital Neoplasms, Female - blood Genital Neoplasms, Female - drug therapy Genital Neoplasms, Female - therapy Graft Survival Health technology assessment Hematopoietic Stem Cell Mobilization HFR Humans Leukapheresis Middle Aged Organoplatinum Compounds - administration & dosage PBPC Peripheral Blood Stem Cell Transplantation - methods Platinum-based chemotherapy Prospective Studies Receptors, Complement 3b - analysis Reticulocyte Count |
| title | Circulating highly fluorescent reticulocytes to predict the adequate harvesting of peripheral blood progenitor cells in platinum-based chemotherapy |
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