Circulating highly fluorescent reticulocytes to predict the adequate harvesting of peripheral blood progenitor cells in platinum-based chemotherapy

We prospectively evaluated whether peripheral blood progenitor cells (PBPC) yield from a single leukapheresis could be predicted by measurement of circulating highly fluorescent reticulocytes (HFR). PBPC were collected from 46 leukaphereses in 15 patients with gynecological cancer following platinum...

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Veröffentlicht in:	Transfusion and apheresis science 2002-12, Vol.27 (3), p.199-202
Hauptverfasser:	Kurata, H, Takakuwa, K, Tsuneki, I, Aoki, Y, Tanaka, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Benzophenoneidum CD34+ cells CFU-GM Combined Modality Therapy Female Flow Cytometry Fluorescent Dyes Fluorometry Genital Neoplasms, Female - blood Genital Neoplasms, Female - drug therapy Genital Neoplasms, Female - therapy Graft Survival Health technology assessment Hematopoietic Stem Cell Mobilization HFR Humans Leukapheresis Middle Aged Organoplatinum Compounds - administration & dosage PBPC Peripheral Blood Stem Cell Transplantation - methods Platinum-based chemotherapy Prospective Studies Receptors, Complement 3b - analysis Reticulocyte Count
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Zusammenfassung:	We prospectively evaluated whether peripheral blood progenitor cells (PBPC) yield from a single leukapheresis could be predicted by measurement of circulating highly fluorescent reticulocytes (HFR). PBPC were collected from 46 leukaphereses in 15 patients with gynecological cancer following platinum-based chemotherapy. Once a level of at least 5.0% HFR was achieved, sufficient PBPC were collected in a single harvest in 71% of the procedures. Whereas, failure to mobilize sufficient PBPC occurred in 24 of 28 leukaphereses when the percentage of circulating HFR was less than 5.0%. In conclusion, circulating HFR may aid in the efficiency of PBPC collections in platinum-based chemotherapy.
ISSN:	1473-0502 1878-1683
DOI:	10.1016/S1473-0502(02)00065-4