Enhancement of the relative uptake of 18F-FDG in mouse fibrosarcoma by rolipram

The effect of rolipram, a selective phosphodiesterase type 4 inhibitor, on the uptake of 18F-fluorodeoxyglucose (18F-FDG) in tumor tissue was examined in mice transplanted with NFSa fibrosarcoma. The uptake indexes of 18F-FDG in the heart, skeletal muscle and brain remarkably decreased after treatme...

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Veröffentlicht in:	Annals of nuclear medicine 2002-11, Vol.16 (7), p.507-510
Hauptverfasser:	Kobayashi, Kaoru, Hosoi, Rie, Momosaki, Sotaro, Koike, Sachiko, Ando, Koichi, Nishimura, Tsunehiko, Inoue, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Brain - metabolism Fibrosarcoma - diagnostic imaging Fibrosarcoma - metabolism Fluorodeoxyglucose F18 - pharmacokinetics Heart - diagnostic imaging Heart - drug effects Hindlimb - surgery Image Enhancement - methods Male Mice Mice, Inbred C3H Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - metabolism Muscle, Skeletal - surgery Myocardium - metabolism Neoplasm Transplantation Plasma - diagnostic imaging Plasma - metabolism Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Rolipram - pharmacology Sensitivity and Specificity Tissue Distribution
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Zusammenfassung:	The effect of rolipram, a selective phosphodiesterase type 4 inhibitor, on the uptake of 18F-fluorodeoxyglucose (18F-FDG) in tumor tissue was examined in mice transplanted with NFSa fibrosarcoma. The uptake indexes of 18F-FDG in the heart, skeletal muscle and brain remarkably decreased after treatment with 3 mg/kg of rolipram (heart: 13%, skeletal muscle: 14%, brain: 31%), but fibrosarcoma tissue showed only a 50% reduction in the uptake index of 18F-FDG. The tumor/muscle ratio of radioactivity 30 min after 18F-FDG injection was consequently enhanced from 1.9 to 6.5 by rolipram. This indicates the possible use of rolipram to enhance the sensitivity of tumor detection, as well as characterization of tumors in 18F-FDG PET.
ISSN:	0914-7187