Purealidin S and Purpuramine J, Bromotyrosine Alkaloids from the Fijian Marine Sponge Druinella sp

Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moder...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-12, Vol.65 (12), p.1798-1801
Hauptverfasser:	Tabudravu, Jioji N, Jaspars, Marcel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Animals Antineoplastic Agents Aplysinellidae Biological and medical sciences Bromobenzenes - chemistry Bromobenzenes - isolation & purification Bromobenzenes - pharmacology bromotyrosine alkaloids Drug Screening Assays, Antitumor Druinella Female Fiji General pharmacology Humans Leukemia Marine Medical sciences Molecular Structure natural products Ovarian Neoplasms Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera Purealidin S purpuramine J Tumor Cells, Cultured - drug effects Tyrosine - analogs & derivatives Tyrosine - chemistry Tyrosine - isolation & purification Tyrosine - pharmacology
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Zusammenfassung:	Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moderate cytotoxic activity. In addition, bioassay data for the eight known bromotyrosine metabolites are reported.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np020275n