Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease

Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease

Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-i...

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Veröffentlicht in:Trends in cell biology 2002-12, Vol.12 (12), p.605-613
Hauptverfasser: Marks, David L, Pagano, Richard E
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological Transport
Cholesterol - metabolism
Endocytosis
Glycosphingolipids - metabolism
Humans
Models, Biological
rab GTP-Binding Proteins - metabolism
Sphingolipidoses - metabolism
Sphingolipidoses - pathology
Sphingolipidoses - therapy
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Zusammenfassung:Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-independent endocytosis of GSLs, the involvement of sphingolipid-cholesterol interactions in perturbation of endocytic trafficking, and potential roles for rab proteins in regulation of GSL transport in SLSDs.
ISSN:0962-8924
DOI:10.1016/s0962-8924(02)02399-1