Isotopically labeled analogues for drug quantitation

Liu et al look at how to overcome problems associated with using isotopically labeled analogues as internal standards for the quantitation of drugs in media. If analytical instrumentation and specimen pretreatment technologies are the "hardware" aspects of the analytical sciences, then ILA...

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Veröffentlicht in:	Analytical chemistry (Washington) 2002-12, Vol.74 (23), p.618A-626A
Hauptverfasser:	LIU, Ray H, LIN, D.-L, CHANG, Wei-Tung, CHIAREIY LIU, TSAY, Wen-Ing, LI, Jih-Heng, KUO, Tsung-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical chemistry Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Drug Monitoring - methods Drug Monitoring - standards Drugs Exact sciences and technology Gas chromatographic methods General pharmacology Isotopes Isotopes - standards Mass Spectrometry Medical sciences Pharmaceutical Preparations - analysis Pharmacology. Drug treatments Reference Standards Spectrometric and optical methods
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Beschreibung
Zusammenfassung:	Liu et al look at how to overcome problems associated with using isotopically labeled analogues as internal standards for the quantitation of drugs in media. If analytical instrumentation and specimen pretreatment technologies are the "hardware" aspects of the analytical sciences, then ILAs may be considered the complementary "software" component that is needed for advanced hardware to reach its full potential in quantitation.
ISSN:	0003-2700 1520-6882
DOI:	10.1021/ac022161m