The Na+/Ca2+ exchange molecule: an overview

An overview of the molecular physiology of the Na(+)/Ca(2+) exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na(+)/Ca(2+) exchanger (NCX1). Parts of the NCS1 mol...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2002-11, Vol.976, p.1-10
Hauptverfasser:	Philipson, Kenneth D, Nicoll, Debora A, Ottolia, Michela, Quednau, Beate D, Reuter, Hannes, John, Scott, Qiu, Zhiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Brain - physiology Heart - physiology Kidney - physiology Models, Molecular Organ Specificity Protein Conformation Sodium-Calcium Exchanger - chemistry Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - physiology
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Beschreibung
Zusammenfassung:	An overview of the molecular physiology of the Na(+)/Ca(2+) exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na(+)/Ca(2+) exchanger (NCX1). Parts of the NCS1 molecule involved in regulation and ion transport have been elucidated, and initial information on the topology and structure is available.
ISSN:	0077-8923