CNS angiitis in graft vs host disease

Graft-vs-host disease (GVHD) is a potentially treatable cause of progressive neurologic decline after bone marrow transplantation (BMT). The authors present histologic confirmation of CNS granulomatous angiitis in a child with chronic GVHD after BMT. Since cranial MRI showed only nonspecific finding...

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Veröffentlicht in:	Neurology 2002-12, Vol.59 (12), p.1994-1997
Hauptverfasser:	MA, M, BARNES, G, PULLIAM, J, JEZEK, D, BAUMANN, R. J, BERGER, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenal Cortex Hormones - therapeutic use Allergic diseases Biological and medical sciences Bone Marrow Transplantation - adverse effects Brain - pathology Cerebrovascular Disorders - drug therapy Cerebrovascular Disorders - etiology Cerebrovascular Disorders - pathology Female Graft vs Host Disease - complications Graft vs Host Disease - pathology Humans Immunopathology Leukemia, Myeloid, Acute - surgery Medical sciences Other localizations Vasculitis - drug therapy Vasculitis - etiology Vasculitis - pathology
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Beschreibung
Zusammenfassung:	Graft-vs-host disease (GVHD) is a potentially treatable cause of progressive neurologic decline after bone marrow transplantation (BMT). The authors present histologic confirmation of CNS granulomatous angiitis in a child with chronic GVHD after BMT. Since cranial MRI showed only nonspecific findings, CNS vasculitis associated with GVHD after BMT may be underdiagnosed.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.WNL.0000038948.09158.A7