Quality of Urography and Renal Clearance of Ionic and Nonionic Contrast Media

Thomsen HS, Vcstergaard A, Dorph S. Quality of urography and renal clearance of ionic and nonionic contrast media. Invest Radiol 1992;27:40–44.The authors evaluated whether urographic quality correlated with patient hydration and the level of their renal function, depending on whether they received ionic or nonionic contrast media. One hundred patients with normal serum creatinine levels were randomly assigned to receive intravenous urography with either an ionic high-osmolar or a nonionic low-osmolar contrast medium. Patient hydration was evaluated by measuring urine osmolality in a sample voided just before the examination. The plasma concentration of iodine was determined in a single blood sample drawn approximately 3 hours later. From these determinations the plasma clearance of contrast medium was calculated. The urograms were assessed blindly with regard to nephrographic and pyelography opacification, as well as overall diagnostic quality. The clearance varied between 42 and 115 ml. x minutes x 1.73 m. No systematic correlation or practical significance was found between the clearances and the urogram quality. A high urinary osmolality before the examination tended to improve quality with both media. It is not possible to assess glomerular filtration rate from nephrographic and pyelographic opacification, or from overall quality of routine urograms in patients with normal serum creatinine levels.