Quinolone Alkaloids, Diacylglycerol Acyltransferase Inhibitors from the Fruits of Evodia rutaecarpa

Abstract From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of EVODIA RUTAECARPA together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4Z,7Z)-4,7-decadien...

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Veröffentlicht in:	Planta medica 2002-12, Vol.68 (12), p.1131-1133
Hauptverfasser:	Ko, Jeong Suk, Rho, Mun-Chual, Chung, Mi Yeon, Song, Hye Young, Kang, Jong Seong, Kim, Koanhoi, Lee, Hyun Sun, Kim, Young Kook
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - antagonists & inhibitors Alkaloids - pharmacology Animals Biological and medical sciences Diacylglycerol O-Acyltransferase Evodia Fruit - chemistry General pharmacology Letter Male Medical sciences Microsomes, Liver - drug effects Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Quinolones - chemistry Quinolones - isolation & purification Quinolones - pharmacology Rats Rats, Sprague-Dawley
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Zusammenfassung:	Abstract From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of EVODIA RUTAECARPA together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4Z,7Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC 50 values of 69.5 μM (1), 23.8 μM (2), 20.1 μM (3) and 13.5 μ (4) .
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2002-36358