Developmental Neurotransmitters?

Previous studies support an early role for neurotransmitter signaling before synaptogenesis, but puzzlingly, a neurological phenotype is absent in embryonic mice that lack vesicular release. Demarque et al. (in this issue of Neuron) now report that early release of transmitter is unconventional in n...

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Veröffentlicht in:	Neuron 2002-12, Vol.36 (6), p.989-991
Hauptverfasser:	Owens, David F., Kriegstein, Arnold R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - embryology Brain - metabolism Cell Communication - physiology Cell Differentiation - physiology Humans Ligands Mice Mutation Neurons Neurosciences Neurotransmitter Agents - metabolism Neurotransmitters Presynaptic Terminals - metabolism Receptors, Neurotransmitter - metabolism Rodents Signal Transduction - physiology Studies Synaptic Transmission - physiology Transmitters
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Zusammenfassung:	Previous studies support an early role for neurotransmitter signaling before synaptogenesis, but puzzlingly, a neurological phenotype is absent in embryonic mice that lack vesicular release. Demarque et al. (in this issue of Neuron) now report that early release of transmitter is unconventional in not requiring action potentials, Ca 2+ entry, or vesicle fusion, thus potentially reconciling the discrepancy.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/S0896-6273(02)01136-4