Artoindonesianin P, a new prenylated flavone with cytotoxic activity from Artocarpus lanceifolius

A new prenylated flavone, named artoindonesianin P ( 1), was isolated from the tree bark of Artocarpus lanceifolius, together with three known related compounds, artobiloxanthone ( 2), cycloartobiloxanthone ( 3) and artonol B ( 4). The structure of artoindonesianin P 1 was determined on the basis of...

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Veröffentlicht in:	Fitoterapia 2002-12, Vol.73 (7), p.668-673
Hauptverfasser:	Hakim, Euis Holisotan, Asnizar, Yurnawilis, Aimi, Norio, Kitajima, Mariko, Takayama, Hiromitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Artocarpus - chemistry Artocarpus lanceifolius Biological and medical sciences Cytotoxicity Flavones Flavonoids - chemistry Flavonoids - pharmacology General pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Mice Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry Tumor Cells, Cultured
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Zusammenfassung:	A new prenylated flavone, named artoindonesianin P ( 1), was isolated from the tree bark of Artocarpus lanceifolius, together with three known related compounds, artobiloxanthone ( 2), cycloartobiloxanthone ( 3) and artonol B ( 4). The structure of artoindonesianin P 1 was determined on the basis of spectral evidence (MS, 1H and 13C NMR) and by comparison with known related compounds. Compounds 1–4 exhibited significant cytotoxicity against murine P388 leukemia cells.
ISSN:	0367-326X
DOI:	10.1016/S0367-326X(02)00226-5