Biomimetic NAD+ Models for Tandem Cofactor Regeneration, Horse Liver Alcohol Dehydrogenase Recognition of 1,4-NADH Derivatives, and Chiral Synthesis

Biomimetic NAD+ Models for Tandem Cofactor Regeneration, Horse Liver Alcohol Dehydrogenase Recognition of 1,4-NADH Derivatives, and Chiral Synthesis

Two tandem catalysis approaches: first, a cofactor regeneration procedure with an NAD+ model and [Cp*Rh(bpy)H]+, which was formed in situ, provided the 1,4‐NADH analogue 1. Cofactor 1 was then used with horse liver alcohol dehydrogenase (HLADH) for the conversion of prochiral ketones into chiral alc...

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Veröffentlicht in:Angewandte Chemie International Edition 2002-02, Vol.41 (3), p.478-481
Hauptverfasser: Lo, H. Christine, Fish, Richard H.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol Dehydrogenase - chemistry
Alcohol Dehydrogenase - metabolism
Animals
asymmetric synthesis
biomimetic synthesis
Biomimetics
Catalysis
cofactors
enzyme catalysis
Horses
Liver - enzymology
Models, Chemical
NAD - analogs & derivatives
NAD - chemical synthesis
NAD - chemistry
redox chemistry
Substrate Specificity
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Zusammenfassung:Two tandem catalysis approaches: first, a cofactor regeneration procedure with an NAD+ model and [Cp*Rh(bpy)H]+, which was formed in situ, provided the 1,4‐NADH analogue 1. Cofactor 1 was then used with horse liver alcohol dehydrogenase (HLADH) for the conversion of prochiral ketones into chiral alcohols (e.g. 2→3).
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20020201)41:3<478::AID-ANIE478>3.0.CO;2-K