Occurrence of Bronchioloalveolar Cell Carcinoma in Two Brothers: Comparison of Clinical Features and Immunohistochemical Findings

It has been suggested that lung cancer sometimes aggregates in families. However, the familial occurrence of bronchioloalveolar carcinoma (BAC) is extremely rare. We present a family in which two brothers had BAC. The clinical features and immunohistochemical findings of BAC in the two brothers were...

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Veröffentlicht in:	Internal Medicine 2002, Vol.41(11), pp.1002-1006
Hauptverfasser:	NANKI, Nobuki, FUJITA, Jiro, OHTSUKI, Yuji, BANDOH, Shuji, OHARA, Nobuya, MIYATANI, Katsuya, YAMAJI, Yasufumi, ISHIDA, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Bronchiolo-Alveolar - genetics Adenocarcinoma, Bronchiolo-Alveolar - pathology Biological and medical sciences bronchioloalveolar carcinoma family Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Lung Neoplasms - genetics Lung Neoplasms - pathology Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pedigree Respiratory system
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Zusammenfassung:	It has been suggested that lung cancer sometimes aggregates in families. However, the familial occurrence of bronchioloalveolar carcinoma (BAC) is extremely rare. We present a family in which two brothers had BAC. The clinical features and immunohistochemical findings of BAC in the two brothers were compared. Immunohistochemical findings revealed that both cases of BAC had very similar immunopathological features in epithelial marker expression. A review of the literature revealed that this is the third case of BACs in a single family. (Internal Medicine 41:1002-1006, 2002)
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.41.1002