Effect of congestive heart failure on the insulin-like growth factor-1 system

Our study shows that in an elderly population of patients hospitalized for congestive heart failure, there was a significant decrease in total insulin-like growth factor-1, a profound reduction in IGF-binding protein-3, and a marked increase in circulating free IGF-1. The decrease in total IGF-1 was...

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Veröffentlicht in:	The American journal of cardiology 2002-12, Vol.90 (12), p.1402-1405
Hauptverfasser:	Anwar, Asif, Gaspoz, Jean-Michel, Pampallona, Sandro, Zahid, Aliya Aftab, Sigaud, Philippe, Pichard, Claude, Brink, Marijke, Delafontaine, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors - therapeutic use Biological and medical sciences Cardiology Cardiology. Vascular system Echocardiography Enzymes Female Heart Heart failure Heart Failure - blood Heart Failure - drug therapy Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Insulin Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - metabolism Male Medical sciences Multivariate Analysis Nutritional Status Older people Prospective Studies
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Zusammenfassung:	Our study shows that in an elderly population of patients hospitalized for congestive heart failure, there was a significant decrease in total insulin-like growth factor-1, a profound reduction in IGF-binding protein-3, and a marked increase in circulating free IGF-1. The decrease in total IGF-1 was not present in patients who received angiotensin-converting enzyme inhibitors.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(02)02885-0