New and Efficient Synthesis of Azabicyclo[4.4.0]alkane Amino Acids by Rh-Catalyzed Cyclohydrocarbonylation

New and Efficient Synthesis of Azabicyclo[4.4.0]alkane Amino Acids by Rh-Catalyzed Cyclohydrocarbonylation

Highly efficient syntheses of azabicyclo[4.4.0]alkane amino acids were achieved by Rh-catalyzed cyclohydrocarbonylation of dipeptides bearing a terminal olefin moiety and a heteroatom nucleophile.

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2002-12, Vol.4 (26), p.4575-4578
Hauptverfasser: Mizutani, Nobuhiro, Chiou, Wen-Hua, Ojima, Iwao
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - chemical synthesis
Aza Compounds - chemical synthesis
Aza Compounds - chemistry
Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic - chemistry
Catalysis
Dipeptides - chemical synthesis
Dipeptides - chemistry
Molecular Mimicry
Peptides, Cyclic - chemical synthesis
Peptides, Cyclic - chemistry
Protein Structure, Secondary
Rhodium - chemistry
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Beschreibung
Zusammenfassung:Highly efficient syntheses of azabicyclo[4.4.0]alkane amino acids were achieved by Rh-catalyzed cyclohydrocarbonylation of dipeptides bearing a terminal olefin moiety and a heteroatom nucleophile.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol026782d