Renin and Angiotensinogen Expression During the Evolution of Diabetes

The expression of renin and angiotensinogen genes and their proteins were studied daring the progression of diabetes using adult BioBreeding spontaneously diabetic rats at 1 day and 2–12 months of diabetes. The number of renin-stained cells per juxtaglomerular apparatus was determined by immunocytoc...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1992-01, Vol.19 (1), p.70-78
Hauptverfasser:	Everett, Allen D, Scott, Joanne, Wilfong, Neysa, Marino, Bradley, Rosenkranz, Roberto P, Inagami, Tadashi, Gomez, R Ariel
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensinogen - genetics Angiotensinogen - metabolism Animals Biological and medical sciences Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Immunohistochemistry Medical sciences Rats Rats, Inbred BB Renin - genetics Renin - metabolism RNA, Messenger - metabolism Tissue Distribution
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Beschreibung
Zusammenfassung:	The expression of renin and angiotensinogen genes and their proteins were studied daring the progression of diabetes using adult BioBreeding spontaneously diabetic rats at 1 day and 2–12 months of diabetes. The number of renin-stained cells per juxtaglomerular apparatus was determined by immunocytochemistry. Initially, at 2 months of diabetes the number of renin-stained cells per juxtaglomerular apparatus increased significantly (p
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.19.1.70