Paradoxical locomotor activating effects of κ-opioid receptor stimulation in the preweanling rat:: Role of the ventromedial thalamus and superior colliculus

Stimulating κ-opioid receptors in the substantia nigra pars reticulata robustly increases the locomotor activity of preweanling rats. To determine whether nigrothalamic and nigrotectal connections are necessary for this κ-opioid-mediated locomotor activity, preweanling rats were given a systemic inj...

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Veröffentlicht in:	Brain research. Developmental brain research 2002-12, Vol.139 (2), p.301-306
Hauptverfasser:	Zavala, A.R., Yoshida, S.T., Osburn, J.R., McDougall, S.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology Analgesics, Non-Narcotic - pharmacology Animals Animals, Newborn Female Locomotor activity Male Motor Activity - drug effects Motor Activity - physiology Movement - drug effects Movement - physiology Neural Pathways - drug effects Neural Pathways - growth & development Neural Pathways - metabolism Rats Rats, Sprague-Dawley Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - metabolism Substantia Nigra - drug effects Substantia Nigra - growth & development Substantia Nigra - metabolism Substantia nigra pars reticulata Superior Colliculi - drug effects Superior Colliculi - growth & development Superior Colliculi - metabolism Superior colliculus U50,488 Ventral Thalamic Nuclei - drug effects Ventral Thalamic Nuclei - growth & development Ventral Thalamic Nuclei - metabolism Ventromedial thalamus κ-Opioid
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Zusammenfassung:	Stimulating κ-opioid receptors in the substantia nigra pars reticulata robustly increases the locomotor activity of preweanling rats. To determine whether nigrothalamic and nigrotectal connections are necessary for this κ-opioid-mediated locomotor activity, preweanling rats were given a systemic injection of saline or 5 mg/kg U50,488 (a κ-opioid receptor agonist) 2 days after receiving sham or bilateral electrolytic lesions of the ventromedial thalamus (VMT) or superior colliculus (SC). Results showed that lesions of the VMT and SC attenuated the U50,488-induced locomotor activity of preweanling rats, indicating that the locomotor activating effects of κ-opioid receptor stimulation require that nigrothalamic and nigrotectal connections be intact.
ISSN:	0165-3806
DOI:	10.1016/S0165-3806(02)00516-3