Homocysteine and risk of open-angle glaucoma

Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have impo...

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Veröffentlicht in:	Journal of Neural Transmission 2002-12, Vol.109 (12), p.1499-1504
Hauptverfasser:	BLEICH, S, JÜNEMANN, A, VON AHSEN, N, LAUSEN, B, RITTER, K, BECK, G, NAUMANN, G. O. H, KORNHUBER, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Case-Control Studies Female Glaucoma Glaucoma and intraocular pressure Glaucoma, Open-Angle - blood Glaucoma, Open-Angle - genetics Homocysteine - blood Humans Male Medical sciences Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Ophthalmology Oxidoreductases Acting on CH-NH Group Donors - genetics Polymorphism, Genetic Prospective Studies
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Zusammenfassung:	Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.
ISSN:	0300-9564 1435-1463
DOI:	10.1007/s007020200097