Intercellular Adhesion Molecule-1 in the Heart

: Intercellular adhesion molecule‐1 (ICAM‐1) belongs to the superfamily of immunoglobulin‐like adhesion molecules. Up‐regulation of ICAM‐1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM‐1—for example, in acute myocardial infarction. Moreover, inhibition...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2002-11, Vol.973 (1), p.573-585
Hauptverfasser:	NIESSEN, HANS W. M., KRIJNEN, PAUL A. J., VISSER, CEES A., MEIJER, CHRIS J. L. M., HACK, C. ERIK
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myocardial infarction Animals Cell Adhesion Cell Line Gene Expression Regulation heart Heart - physiology Heart - physiopathology Humans ICAM-1 Intercellular Adhesion Molecule-1 - genetics Myocardial Infarction - genetics Myocardium - metabolism Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	: Intercellular adhesion molecule‐1 (ICAM‐1) belongs to the superfamily of immunoglobulin‐like adhesion molecules. Up‐regulation of ICAM‐1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM‐1—for example, in acute myocardial infarction. Moreover, inhibition of ICAM‐1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM‐1 may provide a novel therapeutic option for acute myocardial infarction.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.2002.tb04703.x