Precursor Processing by Kex2/Furin Proteases

Precursor Processing by Kex2/Furin Proteases

Much cell-cell signaling relies on the production and secretion of soluble hormones which can then travel to receptors on a target cell. The first proprotein processing protease to be discovered was Kex2 protease from Saccharomyces cerevisiae.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical reviews 2002-12, Vol.102 (12), p.4525-4548
Hauptverfasser: Rockwell, Nathan C, Krysan, Damian J, Komiyama, Tomoko, Fuller, Robert S
Format: Artikel
Sprache:eng
Schlagworte:
Allosteric Regulation
Animals
Biochemistry
Catalysis
Enzymes
Furin
Humans
Peptides - metabolism
Proprotein Convertases
Protein Binding
Proteins
Saccharomyces cerevisiae Proteins
Substrate Specificity
Subtilisins - chemistry
Subtilisins - metabolism
Yeast
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Beschreibung
Zusammenfassung:Much cell-cell signaling relies on the production and secretion of soluble hormones which can then travel to receptors on a target cell. The first proprotein processing protease to be discovered was Kex2 protease from Saccharomyces cerevisiae.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr010168i