Involvement of Sphingosine in Dexamethasone-Induced Thymocyte Apoptosis

Involvement of Sphingosine in Dexamethasone-Induced Thymocyte Apoptosis

: It is generally accepted that ceramide plays an essential role in apoptosis. In this study we suggest that in thymocytes, dexamethasone‐induced apoptosis is mediated by sphingosine rather than ceramide, through the activation of an aSMase and a cerase in a caspase‐dependent manner.

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Veröffentlicht in:Annals of the New York Academy of Sciences 2002-11, Vol.973 (1), p.190-193
Hauptverfasser: LÉPINE, SANDRINE, LAKATOS, BORIS, MAZIERE, PIERRE, COURAGEOT, MARIE-PIERRE, SULPICE, JEAN-CLAUDE, GIRAUD, FRANCOISE
Format: Artikel
Sprache:eng
Schlagworte:
Animals
apoptosis
Cells, Cultured
Ceramides - metabolism
dexamethasone
Dexamethasone - pharmacology
Kinetics
Mice
Sphingomyelin Phosphodiesterase - metabolism
sphingosine
Sphingosine - metabolism
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
T-Lymphocytes - physiology
thymocyte
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Zusammenfassung:: It is generally accepted that ceramide plays an essential role in apoptosis. In this study we suggest that in thymocytes, dexamethasone‐induced apoptosis is mediated by sphingosine rather than ceramide, through the activation of an aSMase and a cerase in a caspase‐dependent manner.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04631.x