Total Synthesis of Amphidinolide T4

Total Synthesis of Amphidinolide T4

Organometallic chemistry in general and catalysis in particular are used in the first total synthesis of amphidinolide T4 (see scheme); a prototype member of a series of macrolide antibiotics of marine origin with rings containing an odd number of carbon atoms.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2002-12, Vol.41 (24), p.4763-4766
Hauptverfasser: Fürstner, Alois, Aïssa, Christophe, Riveiros, Ricardo, Ragot, Jacques
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic - chemistry
Dinoflagellida - chemistry
Lactones - chemical synthesis
Lactones - chemistry
Macrolides
metathesis
Molecular Structure
natural products
ruthenium
total synthesis
zinc
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Beschreibung
Zusammenfassung:Organometallic chemistry in general and catalysis in particular are used in the first total synthesis of amphidinolide T4 (see scheme); a prototype member of a series of macrolide antibiotics of marine origin with rings containing an odd number of carbon atoms.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200290042