Studies on the role of platelet‐activating factor in blood pressure regulation

Circulating levels of 1‐O‐hexadecyl‐2‐acetyl‐sn‐glycero‐3‐phosphocholine (C16PAF) in human subjects were measured by gas chromatography/mass spectrometry using negative ion chemical ionization. The mean (±S.D.) circulating C16PAF levels in patients with essential hypertension (18.1±5.3 pg/mL, n=16)...

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Veröffentlicht in:	Lipids 1991-12, Vol.26 (12Part2), p.1264-1268
Hauptverfasser:	Sakaguchi, Katsuhiko, Morimoto, Shigeto, Masugi, Fuminori, Saeki, Shuichi, Ogihara, Toshio, Yamada, Kouji, Yamatsu, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenals. Interrenals Atrial Natriuretic Factor - pharmacology Biological and medical sciences Blood Pressure - drug effects Creatinine - blood Female Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry - methods Humans Hypertension - blood Hypertension - physiopathology Male Middle Aged Platelet Activating Factor - analogs & derivatives Platelet Activating Factor - metabolism Reference Values Sodium, Dietary - pharmacology Vertebrates: endocrinology
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Zusammenfassung:	Circulating levels of 1‐O‐hexadecyl‐2‐acetyl‐sn‐glycero‐3‐phosphocholine (C16PAF) in human subjects were measured by gas chromatography/mass spectrometry using negative ion chemical ionization. The mean (±S.D.) circulating C16PAF levels in patients with essential hypertension (18.1±5.3 pg/mL, n=16) were not significantly different from those in normotensive subjects (17.2±7.2 pg/mL, n=14). During a salt balance study, high salt intake (20 g/day) significantly increased the circulating level of C16PAF, and changes in circulating C16PAF significantly and positively correlated with changes in mean arterial blood pressure (r=0.47, p
ISSN:	0024-4201 1558-9307
DOI:	10.1007/BF02536544