Diastereoselective Synthesis of Highly Substituted Tetrahydropyran-4-ones

Diastereoselective Synthesis of Highly Substituted Tetrahydropyran-4-ones

Aldol reactions of β-ketoesters with aldehydes followed by a tandem Knoevenagel condensation, with a further equivalent of aldehyde, and intramolecular Michael addition produces single diastereomers of highly substituted tetrahydropyran-4-ones.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2002-12, Vol.4 (25), p.4527-4529
Hauptverfasser: Clarke, Paul A, Martin, William H. C
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aldol reactions of β-ketoesters with aldehydes followed by a tandem Knoevenagel condensation, with a further equivalent of aldehyde, and intramolecular Michael addition produces single diastereomers of highly substituted tetrahydropyran-4-ones.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol027081j