Altered vascular function in fetal programming of hypertension

Reduced endothelium-dependent vasorelaxation partly due to loss of nitric oxide (NO) bioavailability occurs in most cases of chronic hypertension. Intrauterine nutritional deprivation has been associated with increased risk for hypertension and stroke, associated with relaxant dysfunction and decrea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Stroke (1970) 2002-12, Vol.33 (12), p.2992-2998
Hauptverfasser:	LAMIREAU, Delphine, NUYT, Anne Monique, XIN HOU, BERNIER, Sylvie, BEAUCHAMP, Martin, GOBEIL, Fernand JR, LAHAIE, Isabelle, VARMA, Daya R, CHEMTOB, Sylvain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chronic Disease Cyclic GMP - analogs & derivatives Cyclic GMP - metabolism Cyclic GMP - pharmacology Dietary Proteins - pharmacology Disease Models, Animal Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Enzyme Inhibitors - pharmacology Experimental diseases Female Guanylate Cyclase Hypertension - etiology Hypertension - physiopathology In Vitro Techniques Medical sciences Microcirculation - drug effects Microcirculation - physiopathology Neurotransmitter Agents - pharmacology Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - metabolism Pia Mater - blood supply Pregnancy Prenatal Exposure Delayed Effects Protein Deficiency - physiopathology Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - metabolism Signal Transduction - drug effects Soluble Guanylyl Cyclase Vasodilation - drug effects Vasodilator Agents - pharmacology Vasomotor System - drug effects Vasomotor System - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Reduced endothelium-dependent vasorelaxation partly due to loss of nitric oxide (NO) bioavailability occurs in most cases of chronic hypertension. Intrauterine nutritional deprivation has been associated with increased risk for hypertension and stroke, associated with relaxant dysfunction and decreased vascular compliance, but the underlying mechanisms are not known. The present studies were undertaken to investigate whether endothelial dysfunction associated with altered NO-dependent vasodilatation pathways is also observed in a model of in utero programming of hypertension. Pregnant Wistar rats were fed a normal (18%), low (9%), or very low (6%) protein isocaloric diet during gestation. Vasomotor response of resistance cerebral microvessels (
ISSN:	0039-2499 1524-4628
DOI:	10.1161/01.STR.0000039340.62995.F2