Development of intranasal lactocin (oxytocin) drops technology

Pure oxytocin substance was obtained from posterior part of cattle pituitary gland by high pressure liquid chromatography. Biological activity of the substance--450-500 IU/mg. Chromatographically pure Oxytocin substance was used in developing two different compositions of Lactocin intranasal drops (...

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Veröffentlicht in:	Medicina (Kaunas, Lithuania) Lithuania), 2002, Vol.38 (6), p.655-658
Hauptverfasser:	Klimas, Rimantas, Baranauskas, Algirdas, Gendrolis, Antanas
Format:	Artikel
Sprache:	lit
Schlagworte:	Adult Animals Breast Feeding Chickens Chromatography, High Pressure Liquid Drug Stability Female Humans Lactation - drug effects Male Oxytocin - administration & dosage Oxytocin - analysis Oxytocin - isolation & purification Oxytocin - pharmacology Oxytocin - standards Pharmaceutical Solutions - standards Rats Technology, Pharmaceutical Temperature Time Factors
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Beschreibung
Zusammenfassung:	Pure oxytocin substance was obtained from posterior part of cattle pituitary gland by high pressure liquid chromatography. Biological activity of the substance--450-500 IU/mg. Chromatographically pure Oxytocin substance was used in developing two different compositions of Lactocin intranasal drops (40 IU/ml). Stability evaluation was performed for 2 year period. The technical documentation was prepared on the basis of the research results. Lactocin is active preparation helping lactation and is indicated for lactostasis treatment and its prophylaxis after delivery.
ISSN:	1010-660X