Oral citicoline in acute ischemic Stroke: An individual patient data pooling analysis of clinical trials

No single neuroprotective agent has been shown to influence outcome after acute stroke. Citicoline has been studied worldwide in many clinical trials with positive findings, but only 1 trial has obtained significant results in the primary efficacy variables. Our objective was to evaluate the effects...

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Veröffentlicht in:	Stroke (1970) 2002-12, Vol.33 (12), p.2850-2857
Hauptverfasser:	DAVALOS, Antoni, CASTILLO, José, LOZANO, Rafael, ALVAREZ-SABIN, José, SECADES, Julio J, MERCADAL, Joan, LOPEZ, Sonia, COBO, Erik, WARACH, Steven, SHERMAN, David, CLARK, Wayne M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Administration, Oral Aged Biological and medical sciences Brain Ischemia - complications Brain Ischemia - drug therapy Cytidine Diphosphate Choline - administration & dosage Dose-Response Relationship, Drug Double-Blind Method Female Humans Male Medical sciences Neurology Neuropharmacology Neuroprotective Agents - administration & dosage Odds Ratio Pharmacology. Drug treatments Prospective Studies Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Randomized Controlled Trials as Topic - statistics & numerical data Recovery of Function - drug effects Severity of Illness Index Stroke - complications Stroke - drug therapy Time Factors Treatment Outcome Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	No single neuroprotective agent has been shown to influence outcome after acute stroke. Citicoline has been studied worldwide in many clinical trials with positive findings, but only 1 trial has obtained significant results in the primary efficacy variables. Our objective was to evaluate the effects of oral citicoline in patients with acute ischemic stroke by a data pooling analysis of clinical trials. The primary efficacy end point chosen was the common evaluation of recovery, combining National Institutes of Health Stroke Scale /=8, and prior modified Rankin Scale score
ISSN:	0039-2499 1524-4628
DOI:	10.1161/01.STR.0000038691.03334.71